Principal Investigator

Principal Investigator – Clinical Research

Location: Southern California
Employment Type: Full-Time, Onsite
Compensation: $300,000–$350,000+ base, depending on experience
Relocation: Available for qualified candidates

The Opportunity

We are partnering with a growing site network seeking an experienced Principal Investigator (PI) for a full-time PI opportunity in Southern California.

This is a high-impact opportunity for an established clinical research physician who wants to take a leading role within a growing research program. Unlike some of our other physician opportunities, previous Principal Investigator experience is required for this position.

The ideal candidate will combine strong clinical research experience with a background treating patients with metabolic, hepatic and/or cardiometabolic conditions.

Key Responsibilities

• Serve as Principal Investigator for assigned clinical research studies

• Provide overall medical and scientific oversight of clinical trials

• Ensure studies are conducted in accordance with protocols, GCP, regulatory requirements, and patient-safety standards

• Evaluate potential study participants and determine medical eligibility

• Provide ongoing medical oversight for enrolled participants

• Review clinical data, laboratory results, adverse events, serious adverse events, and other relevant medical information

• Make appropriate medical and safety decisions throughout study participation

• Work closely with clinical research coordinators, site leadership, sponsors, and other research professionals

• Provide medical leadership and guidance to the clinical research team

• Participate in sponsor, investigator, and regulatory meetings as needed

• Maintain appropriate study documentation and regulatory compliance

• Support a 24-hour emergency phone line for rare serious adverse events or hospitalizations on a rotating/as-needed basis; this is phone coverage only and does not require returning to the site

Qualifications

Required:

• MD or DO degree

• Active, unrestricted California medical license in good standing

• Board Certified OR Board Eligible in an applicable medical specialty

• Previous experience serving as a Principal Investigator on clinical trials

• Minimum of 2 years of post-training clinical practice experience treating patients

• Relevant experience with metabolic, hepatic, cardiometabolic, or related patient populations

• No restrictive covenant or non-compete that would interfere with accepting the position

• Ability to work onsite full-time in Southern California

• Strong understanding of physician responsibilities within clinical research

• Commitment to patient safety, data quality, and regulatory compliance

Highly Preferred:

• Internal Medicine, Family Medicine, Hepatology, or a related clinical background

• Experience treating patients with metabolic or liver-related conditions

• Experience conducting industry-sponsored clinical trials

• Strong knowledge of GCP and clinical research regulations

• Experience working collaboratively with sponsors, CROs, and research-site teams

• Demonstrated ability to provide medical leadership within a clinical research environment

Compensation & Relocation

The anticipated base salary range for this position is $300,000–$350,000+, depending on experience, qualifications, and overall fit.

There is flexibility for an exceptional, highly experienced Principal Investigator.

Relocation assistance is available for qualified candidates who are interested in moving to Southern California.

Why Consider This Opportunity?

This is an opportunity for an experienced PI to take on a highly visible physician leadership role within an expanding clinical research organization.

You'll have the ability to bring your existing research expertise into an environment where experienced physician leadership is highly valued, while continuing to work directly with patients and industry-sponsored clinical trials.

For physicians outside of California who already hold an active California medical license, relocation assistance provides an opportunity to be considered without currently residing in the area.

Interested physicians with prior Principal Investigator experience are encouraged to apply or reach out confidentially to learn more.